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*Urology Job Opportunity for Locums or Temporary to Permanent in Minnesota!* :: Minnesota :: CompHealth Inc
Job 0131481-0020 Temporary opportunity while searching for a permanent physician. If you are licensed in Minnesota and are available in 2010, please contact our Physician Recruiter for full details!
*Immediate Urology Job Opportunity for a Locum Tenen Physician in Ohio!* :: Ohio :: CompHealth Inc
Job 0844059-0005 Our client has an immediate need for a BC/BE Urologist. If you have an Ohio license and are seeking immediate work please contact one of our Physician Recruiters here at CompHealth.
1.5 Hours to San Diego, 100% Collections after Base, Low Call, #3009 :: California :: Timeline Recruiting
Are you tired of the cold? Come and experience one of the last affordable communities in southern California. This is not the California of smog, congestion and over priced housing. This is the California
Urology / Nephrology News From Medical News Today
Heart Failure Patients With Kidney Dysfunction Don't Recover Well After Hospital Discharge
Wed, 18 Nov 2009 05:00:00 -0800
Most heart failure patients who develop kidney failure in the hospital do not recover from it before going home and are at increased risk of either being re-hospitalized or dying within the year, according to a Henry Ford Hospital study. The study's gloomy finding is the first time researchers linked long-term health outcomes with declining kidney function in patients hospitalized for heart failure.
Seattle Genetics Initiates Phase I Clinical Trial Of Antibody-Drug Conjugate SGN-75
Wed, 18 Nov 2009 00:00:00 -0800
Seattle Genetics, Inc. (Nasdaq: SGEN) announced that it has initiated a phase I clinical trial of SGN-75 for metastatic renal cell carcinoma and relapsed and refractory non-Hodgkin lymphoma. SGN-75 is an antibody-drug conjugate (ADC) targeting CD70 that utilizes the company's proprietary technology.
Bladder Cancer Risks Increase Over Time For Smokers
Tue, 17 Nov 2009 04:00:00 -0800
Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in New Hampshire than that among nonsmokers in 2001-2004, according to a new study published online November 16 in the Journal of the National Cancer Institute.
BMC Urology - Latest Articles
Percutaneous nephrolithotomy in horseshoe Kidneys: is rigid nephroscopy sufficient tool for complete clearance? a case series study
Mohamed El GhoneimyAhmed KoderaAshraf EmranTamer OrbanAhmed ShabanMohamed El Gammal Mon, 16 Nov 2009 00:00:00 -0000
Background: this study represents a case series to evaluate how successful is the rigid percutaneous nephroscopy as a tool for clearance of all stones in various locations in horseshoe kidneys. Methods: Between 2005 and 2009, we carried out PCNL (percutaneous nephrolithotomy) for calculi in horseshoe kidneys in 21 renal units (17 patients) in our department. The indications were large stone burden in 18 units and failed SWL( shock wave lithotripsy) in 3 renal units. All procedures were done under general anesthesia; using fluoroscopic guidance for localization and standard alkan dilatation followed by rigid nephroscopy and stone extraction with or without stone disintegration. We analyzed our results regarding the site and number of the required access, the intra and postoperative complications, the presence of any residual stones, as well as their location. Results: The procedure was completed, using a single access tract in 20 renal units, with the site of puncture being the upper calyx in nine units and the posterior middle calyx in eleven units. Only in one renal unit, two access tracts (an upper and a lower calyceal) were required for completion and a supracostal puncture was required in another case. There was no significant intraoperative bleeding and no blood transfusion was required in any patient. A pelvic perforation occurred in one case, requiring longer PCN (percutaneous nephrostomy) drainage. One patient with infection stones suffered urosepsis postoperatively which was successfully managed. Three cases had residual stones, all located in the renal isthmus, all residuals were un approachable with the rigid instrument; resulting in a overall stone-free rate of 85.7 % at discharge. Conclusion: Percutaneous nephrolithotomy is generally safe and successful in the management of stones in horseshoe kidneys. However, location of the stones in these patients is crucial to decide the proper tool for optimal stone clearance result.
Pharmacologic attenuation of pelvic pain in a Murine model of interstitial cystitis
Charles RudickAnthony SchaefferDavid Klumpp Thu, 12 Nov 2009 00:00:00 -0000
Background: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a bladder disease that causes debilitating pelvic pain of unknown origin, and IC/PBS symptoms correlate with elevated bladder lamina propria mast cell counts. Similar to IC/PBS patients, pseudorabies virus (PRV) infection in mice induces a neurogenic cystitis associated with bladder lamina propria mast cell accumulation and pelvic pain. We evaluated several drugs to determine the effectiveness of reducing PRV-induced pelvic pain. Methods: Neurogenic cystitis was induced by the injection of Bartha's strain of PRVinto the abductor caudalis dorsalis tail base muscle of female C57BL/6 mice. Therapeutic modulation of pelvic pain was assessed daily for five days using von Frey filament stimulation to the pelvic region to quantify tactile allodynia. Results: Significant reduction of PRV-induced pelvic pain was observed for animals treated with antagonists of neurokinin receptor 1 and histamine receptors. In contrast, the H1R antagonist hydroxyzine, proton pump inhibitors, a histamine receptor 3 agonist, and gabapentin had little or no effect on PRV-induced pelvic pain. Conclusions: These data demonstrate that bladder-associated pelvic pain is attenuated by antagonists of NK1R, H2R, and H1R. Therefore, NK1R, H2R and H1R represent direct therapeutic targets for pain in IC/PBS and potentially other chronic pain conditions.
Donor site morbidity in oral mucosa graft urethroplasty: implications of tobacco consumption
Rahul Janak SinhaVishwajeet SinghS SankhwarDivakar Dalela Mon, 21 Sep 2009 00:00:00 -0000
Background: The purpose of this prospective study was to evaluate the donor site morbidity in patients who have undergone oral mucosa graft urethroplasty for stricture of the urethra. The impact of smoking and oral consumption of tobacco and/or paan masala on the donor site was also assessed. This study is probably the first of its kind where the affect of smoking, paan masala and tobacco chewing on the donor site morbidity has been documented. Methods: Forty-eight patients suffering from stricture of the urethra underwent oral mucosa graft urethroplasty between July 2005 and December 2007. The patients were divided into two groups (users or non-users) based on tobacco consumption and oral hygiene. The donor site was evaluated at frequent intervals for pain, swelling, numbness, bleeding, salivation and tightness of mouth. Results: Donor site morbidity was more in users with poor oral hygiene. Pain scores were higher amongst the users and the morbidity persisted longer in the users compared to non-users with good oral hygiene. Conclusion: Patients who consume tobacco and have poor oral hygiene should be warned regarding poorer outcomes after oral mucosa graft urethroplasty.
A systematic review of the diagnostic accuracy of prostate specific antigen
Philip HarveyAmman BasuitaDeborah EndersbyBen CurtisAphrodite IacovidouMary Walker Thu, 10 Sep 2009 00:00:00 -0000
Background: Prostate cancer is the fourth commonest cancer in the UK, and the incidence is rising. The reference standard for diagnosing this condition is prostate biopsy, an invasive procedure.This study systematically reviews recent literature on tPSA accuracy. The time period was restricted to ensure that the estimates referred to contemporary tPSA tests and prostate cancer reference standards. The focus of this review was restricted to European populations as tPSA levels are known to vary by population group. Methods: Medline was searched (from 01/1998 to 01/2008) and Embase (from 01/1998 to 01/2008), which returned 3087 citations. These were assessed by 6 reviewers, who shortlisted 54 of possible relevance. 2 reviewers assessed each using the following inclusion criteria: data collection between 1998-2008; tPSA measurements for all participants; histological confirmation of the diagnosis; samples from a European population and sufficient data to calculate 2 × 2 tables. The final set of 10 included studies represented 5373 participants. Quality of the included studies was assessed in duplicate using criteria suggested by the Cochrane Collaboration. Review Manager 5.0 software was used to analyse the data, including plotting a series of summary receiver operator curve spaces (SROC). Results: tPSA sensitivities ranged from 0.78 to 1.00 and specificities from 0.06 to 0.66. Positive likelihood ratios ranged from 0.83 to 2.90 and negative likelihood ratios ranged from 0.00 to 3.75 Conclusion: tPSA has a role to play as one of several indicators for prostate biopsy along with abnormal digital rectal examination and urinary symptoms. However, tPSA test has a high false positive and significant false negative rate. It is important that clinicians understand these limitations.
Commentary: the role of cytologic analysis of voided urine in the work-up of asymptomatic microhematuria
Deep TrivediEdward Messing Thu, 10 Sep 2009 00:00:00 -0000
Microscopic hematuria is a common finding in patients presenting to both primary care doctors as well as urologists. Sources of microscopic hematuria include infection, stones, inflammatory disorders as well as cancer of the genitourinary tract, particularly urothelial cancer. A primary focus in the urologic workup of hematuria is to rule out cancer. This is done using radiographic studies as well as procedures such as cystoscopy and bladder biopsy. As the authors state in their article titled "The utility of serial urinary cytology in the initial evaluation of the patient with microscopic hematuria", cytologic analysis of voided urine, though attractive due to its noninvasive nature, has been found to have the neither the sensitivity, cost-effectiveness, nor the ease of administration necessary to replace more invasive diagnostics in the evaluation of microscopic hematuria.
Utility of serial urinary cytology in the initial evaluation of the patient with microscopic hematuria
Kogenta NakamuraAli KasraeianKenneth IczkowskiMyron ChangJohn PendletonSatoshi AnaiCharles Rosser Thu, 10 Sep 2009 00:00:00 -0000
Background: We determine the utility of serial urinary cytologies in patients presenting with microscopic hematuria who were evaluated with upper and lower urinary tract studies to rule out a malignancy. Methods: Two hundred and thirty-seven patients with the diagnosis of microscopic hematuria were evaluated at an inner-city tertiary care hospital. Of these 239 patients, 182 patients had 405 cytologies obtained as part of their evaluation for hematuria. In addition, all patients had their lower urinary tract and upper tract thoroughly evaluated. Results: Two hundred and seventy four cytology samples were read as normal, 104 (26%) as atypia, 7 (2%) as suspicious/malignant, and 20 (5%) as unsatisfactory. Seventeen patients (9.3%) had biopsy confirmed bladder cancer. Of these 17 patients, 2 had normal cytology, 11 had atypia, and 5 had suspicious/malignant. No patient had a positive cytology and a negative biopsy. Overall the number of hematuric patients harboring bladder cancer was small (7%). Cytology #1 detected 4 cases of cancer, cytology #2 detected an additional case and cytology #3 did not detect any additional cancers. Conclusion: Because of this low prevalence of bladder cancer in patients presenting with microscopic hematuria and the low sensitivity of detecting bladder cancers, the utility of urinary cytology in the initial evaluation of patients with hematuria may be minimal. The exact role of urinary cytology in the evaluation of hematuria is unknown.
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*Urology Job Opportunity for Locums or Temporary to Permanent in Minnesota!* :: Minnesota :: CompHealth Inc
Job 0131481-0020 Temporary opportunity while searching for a permanent physician. If you are licensed in Minnesota and are available in 2010, please contact our Physician Recruiter for full details!
*Immediate Urology Job Opportunity for a Locum Tenen Physician in Ohio!* :: Ohio :: CompHealth Inc
Job 0844059-0005 Our client has an immediate need for a BC/BE Urologist. If you have an Ohio license and are seeking immediate work please contact one of our Physician Recruiters here at CompHealth.
1.5 Hours to San Diego, 100% Collections after Base, Low Call, #3009 :: California :: Timeline Recruiting
Are you tired of the cold? Come and experience one of the last affordable communities in southern California. This is not the California of smog, congestion and over priced housing. This is the California
Urology / Nephrology News From Medical News Today
Heart Failure Patients With Kidney Dysfunction Don't Recover Well After Hospital Discharge
Wed, 18 Nov 2009 05:00:00 -0800
Most heart failure patients who develop kidney failure in the hospital do not recover from it before going home and are at increased risk of either being re-hospitalized or dying within the year, according to a Henry Ford Hospital study. The study's gloomy finding is the first time researchers linked long-term health outcomes with declining kidney function in patients hospitalized for heart failure.
Seattle Genetics Initiates Phase I Clinical Trial Of Antibody-Drug Conjugate SGN-75
Wed, 18 Nov 2009 00:00:00 -0800
Seattle Genetics, Inc. (Nasdaq: SGEN) announced that it has initiated a phase I clinical trial of SGN-75 for metastatic renal cell carcinoma and relapsed and refractory non-Hodgkin lymphoma. SGN-75 is an antibody-drug conjugate (ADC) targeting CD70 that utilizes the company's proprietary technology.
Bladder Cancer Risks Increase Over Time For Smokers
Tue, 17 Nov 2009 04:00:00 -0800
Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in New Hampshire than that among nonsmokers in 2001-2004, according to a new study published online November 16 in the Journal of the National Cancer Institute.
BMC Urology - Latest Articles
Percutaneous nephrolithotomy in horseshoe Kidneys: is rigid nephroscopy sufficient tool for complete clearance? a case series study
Mohamed El GhoneimyAhmed KoderaAshraf EmranTamer OrbanAhmed ShabanMohamed El Gammal Mon, 16 Nov 2009 00:00:00 -0000
Background: this study represents a case series to evaluate how successful is the rigid percutaneous nephroscopy as a tool for clearance of all stones in various locations in horseshoe kidneys. Methods: Between 2005 and 2009, we carried out PCNL (percutaneous nephrolithotomy) for calculi in horseshoe kidneys in 21 renal units (17 patients) in our department. The indications were large stone burden in 18 units and failed SWL( shock wave lithotripsy) in 3 renal units. All procedures were done under general anesthesia; using fluoroscopic guidance for localization and standard alkan dilatation followed by rigid nephroscopy and stone extraction with or without stone disintegration. We analyzed our results regarding the site and number of the required access, the intra and postoperative complications, the presence of any residual stones, as well as their location. Results: The procedure was completed, using a single access tract in 20 renal units, with the site of puncture being the upper calyx in nine units and the posterior middle calyx in eleven units. Only in one renal unit, two access tracts (an upper and a lower calyceal) were required for completion and a supracostal puncture was required in another case. There was no significant intraoperative bleeding and no blood transfusion was required in any patient. A pelvic perforation occurred in one case, requiring longer PCN (percutaneous nephrostomy) drainage. One patient with infection stones suffered urosepsis postoperatively which was successfully managed. Three cases had residual stones, all located in the renal isthmus, all residuals were un approachable with the rigid instrument; resulting in a overall stone-free rate of 85.7 % at discharge. Conclusion: Percutaneous nephrolithotomy is generally safe and successful in the management of stones in horseshoe kidneys. However, location of the stones in these patients is crucial to decide the proper tool for optimal stone clearance result.
Pharmacologic attenuation of pelvic pain in a Murine model of interstitial cystitis
Charles RudickAnthony SchaefferDavid Klumpp Thu, 12 Nov 2009 00:00:00 -0000
Background: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a bladder disease that causes debilitating pelvic pain of unknown origin, and IC/PBS symptoms correlate with elevated bladder lamina propria mast cell counts. Similar to IC/PBS patients, pseudorabies virus (PRV) infection in mice induces a neurogenic cystitis associated with bladder lamina propria mast cell accumulation and pelvic pain. We evaluated several drugs to determine the effectiveness of reducing PRV-induced pelvic pain. Methods: Neurogenic cystitis was induced by the injection of Bartha's strain of PRVinto the abductor caudalis dorsalis tail base muscle of female C57BL/6 mice. Therapeutic modulation of pelvic pain was assessed daily for five days using von Frey filament stimulation to the pelvic region to quantify tactile allodynia. Results: Significant reduction of PRV-induced pelvic pain was observed for animals treated with antagonists of neurokinin receptor 1 and histamine receptors. In contrast, the H1R antagonist hydroxyzine, proton pump inhibitors, a histamine receptor 3 agonist, and gabapentin had little or no effect on PRV-induced pelvic pain. Conclusions: These data demonstrate that bladder-associated pelvic pain is attenuated by antagonists of NK1R, H2R, and H1R. Therefore, NK1R, H2R and H1R represent direct therapeutic targets for pain in IC/PBS and potentially other chronic pain conditions.
Donor site morbidity in oral mucosa graft urethroplasty: implications of tobacco consumption
Rahul Janak SinhaVishwajeet SinghS SankhwarDivakar Dalela Mon, 21 Sep 2009 00:00:00 -0000
Background: The purpose of this prospective study was to evaluate the donor site morbidity in patients who have undergone oral mucosa graft urethroplasty for stricture of the urethra. The impact of smoking and oral consumption of tobacco and/or paan masala on the donor site was also assessed. This study is probably the first of its kind where the affect of smoking, paan masala and tobacco chewing on the donor site morbidity has been documented. Methods: Forty-eight patients suffering from stricture of the urethra underwent oral mucosa graft urethroplasty between July 2005 and December 2007. The patients were divided into two groups (users or non-users) based on tobacco consumption and oral hygiene. The donor site was evaluated at frequent intervals for pain, swelling, numbness, bleeding, salivation and tightness of mouth. Results: Donor site morbidity was more in users with poor oral hygiene. Pain scores were higher amongst the users and the morbidity persisted longer in the users compared to non-users with good oral hygiene. Conclusion: Patients who consume tobacco and have poor oral hygiene should be warned regarding poorer outcomes after oral mucosa graft urethroplasty.
A systematic review of the diagnostic accuracy of prostate specific antigen
Philip HarveyAmman BasuitaDeborah EndersbyBen CurtisAphrodite IacovidouMary Walker Thu, 10 Sep 2009 00:00:00 -0000
Background: Prostate cancer is the fourth commonest cancer in the UK, and the incidence is rising. The reference standard for diagnosing this condition is prostate biopsy, an invasive procedure.This study systematically reviews recent literature on tPSA accuracy. The time period was restricted to ensure that the estimates referred to contemporary tPSA tests and prostate cancer reference standards. The focus of this review was restricted to European populations as tPSA levels are known to vary by population group. Methods: Medline was searched (from 01/1998 to 01/2008) and Embase (from 01/1998 to 01/2008), which returned 3087 citations. These were assessed by 6 reviewers, who shortlisted 54 of possible relevance. 2 reviewers assessed each using the following inclusion criteria: data collection between 1998-2008; tPSA measurements for all participants; histological confirmation of the diagnosis; samples from a European population and sufficient data to calculate 2 × 2 tables. The final set of 10 included studies represented 5373 participants. Quality of the included studies was assessed in duplicate using criteria suggested by the Cochrane Collaboration. Review Manager 5.0 software was used to analyse the data, including plotting a series of summary receiver operator curve spaces (SROC). Results: tPSA sensitivities ranged from 0.78 to 1.00 and specificities from 0.06 to 0.66. Positive likelihood ratios ranged from 0.83 to 2.90 and negative likelihood ratios ranged from 0.00 to 3.75 Conclusion: tPSA has a role to play as one of several indicators for prostate biopsy along with abnormal digital rectal examination and urinary symptoms. However, tPSA test has a high false positive and significant false negative rate. It is important that clinicians understand these limitations.
Commentary: the role of cytologic analysis of voided urine in the work-up of asymptomatic microhematuria
Deep TrivediEdward Messing Thu, 10 Sep 2009 00:00:00 -0000
Microscopic hematuria is a common finding in patients presenting to both primary care doctors as well as urologists. Sources of microscopic hematuria include infection, stones, inflammatory disorders as well as cancer of the genitourinary tract, particularly urothelial cancer. A primary focus in the urologic workup of hematuria is to rule out cancer. This is done using radiographic studies as well as procedures such as cystoscopy and bladder biopsy. As the authors state in their article titled "The utility of serial urinary cytology in the initial evaluation of the patient with microscopic hematuria", cytologic analysis of voided urine, though attractive due to its noninvasive nature, has been found to have the neither the sensitivity, cost-effectiveness, nor the ease of administration necessary to replace more invasive diagnostics in the evaluation of microscopic hematuria.
Utility of serial urinary cytology in the initial evaluation of the patient with microscopic hematuria
Kogenta NakamuraAli KasraeianKenneth IczkowskiMyron ChangJohn PendletonSatoshi AnaiCharles Rosser Thu, 10 Sep 2009 00:00:00 -0000
Background: We determine the utility of serial urinary cytologies in patients presenting with microscopic hematuria who were evaluated with upper and lower urinary tract studies to rule out a malignancy. Methods: Two hundred and thirty-seven patients with the diagnosis of microscopic hematuria were evaluated at an inner-city tertiary care hospital. Of these 239 patients, 182 patients had 405 cytologies obtained as part of their evaluation for hematuria. In addition, all patients had their lower urinary tract and upper tract thoroughly evaluated. Results: Two hundred and seventy four cytology samples were read as normal, 104 (26%) as atypia, 7 (2%) as suspicious/malignant, and 20 (5%) as unsatisfactory. Seventeen patients (9.3%) had biopsy confirmed bladder cancer. Of these 17 patients, 2 had normal cytology, 11 had atypia, and 5 had suspicious/malignant. No patient had a positive cytology and a negative biopsy. Overall the number of hematuric patients harboring bladder cancer was small (7%). Cytology #1 detected 4 cases of cancer, cytology #2 detected an additional case and cytology #3 did not detect any additional cancers. Conclusion: Because of this low prevalence of bladder cancer in patients presenting with microscopic hematuria and the low sensitivity of detecting bladder cancers, the utility of urinary cytology in the initial evaluation of patients with hematuria may be minimal. The exact role of urinary cytology in the evaluation of hematuria is unknown.
Sites:
About Urology: Search the power of About's network of topicsDitropan XL: DITROPAN XL (oxybutynin chloride) reduces syptoms of overactive bladder and frequent urination.
DrRajMD.com: DrRajMD.com, providing physician (Dr. Gene Rajaratnam) monitored information on all major urological topis, such as Prostate Cancer, BPH, Prostate Ultrasound and Biopsy, Prostate Conditions, Acute Bacterial Prostatitis, Prostate Cancer, Removal of the Prostate, Kidney Stones, Kidney Cancer, Male...
Global Lithotripsy Services: A Lithotripsy (ESWL, ESWT) Service Provider
Muljibhai Patel Urological Hospital: MPUH is one of its kind in Asia and the first hospital in the country devoted entirely to Nephrology and Urology. Includes information about services, training, research and case studies.
University of Maryland Urologic Surgery Division: Offers a clear and comprehensive explanation of urinary system anatomy and diseases such as kidney stones and impotence with links to related Medical Center services.
Urology Department at Loyola University Medical Center: The Department of Urology at Loyola University Chicago provides a full range of services for children and adults with concerns or problems of the urinary tract or male reproductive system.
Urology jobs: Urology jobs board with automatic email updates with a directory of recruitment firms.
This directory is based on the Open Directory and may have been modified
