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Locum Tenens Pathology Job in Locums position available in WA for board-certified Pathologist Washington with Weatherby Locums
Job 9558851-0012 Pathology board-certified physician needed for two weeks a month in Seattle, Washington area free-standing lab setting. Private lab facility does not require hospital privileging, but
Permanent Pathology Job in Upper Peninsula of Michigan Michigan with Enterprise Medical Services
Need Pathologist to join 2 others in practice. This would be an employed position thru hospital. They will also affiliate with 1-2 other hospitals in the area. Must be B/E or B/C in Pathology for
Permanent Pathology Job in Big Apple New York with Millie Nixon, By Appointment Only
Pathologist(s) We have opportunity for Board Certified/Board Eligible physicians with entry level to advanced experience and current licensure in the State of New York. The job will require viewing
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusions: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus
Yeliz Genç, Reşit Özkanca and Yunus Bekdemir Wed, 20 Aug 2008 00:00:00 -0000
Background: Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S. aureus due to methicillin resistance. Methods: Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S. aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S. aureus ATCC 29213 was also tested. Results: The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S. aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S. aureus MRSAisolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. Conclusion: This study may help to suggest an alternative possible leading compound for development of new antimicrobial agents against MRSA and MSSA resistant S. aureus. It was also shown here that that clinical isolates of 50 S. aureus have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for S. aureus need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.
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Locum Tenens Pathology Job in Locums position available in WA for board-certified Pathologist Washington with Weatherby Locums
Job 9558851-0012 Pathology board-certified physician needed for two weeks a month in Seattle, Washington area free-standing lab setting. Private lab facility does not require hospital privileging, but
Permanent Pathology Job in Upper Peninsula of Michigan Michigan with Enterprise Medical Services
Need Pathologist to join 2 others in practice. This would be an employed position thru hospital. They will also affiliate with 1-2 other hospitals in the area. Must be B/E or B/C in Pathology for
Permanent Pathology Job in Big Apple New York with Millie Nixon, By Appointment Only
Pathologist(s) We have opportunity for Board Certified/Board Eligible physicians with entry level to advanced experience and current licensure in the State of New York. The job will require viewing
Annals of Clinical Microbiology and Antimicrobials - Latest articles
Brachyspira pilosicoli bloodstream infections: Case report and review of the literature
Lilia Bait-Merabet, Arnaud Thille, Patrick Legrand, Christian Brun-Buisson and Vincent Cattoir Thu, 25 Sep 2008 00:00:00 -0000
Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.
Predicting the sensitivity and specificity of published real-time PCR assays
Gordon H Lemmon and Shea N Gardner Thu, 25 Sep 2008 00:00:00 -0000
Background: In recent years real-time PCR has become a leading technique for nucleic acid detection and quantification. These assays have the potential to greatly enhance efficiency in the clinical laboratory. Choice of primer and probe sequences is critical for accurate diagnosis in the clinic, yet current primer/probe signature design strategies are limited, and signature evaluation methods are lacking. Methods: We assessed the quality of a signature by predicting the number of true positive, false positive and false negative hits against all available public sequence data. We found real-time PCR signatures described in recent literature and used a BLAST search based approach to collect all hits to the primer-probe combinations that should be amplified by real-time PCR chemistry. We then compared our hits with the sequences in the NCBI taxonomy tree that the signature was designed to detect. Results: We found that many published signatures have high specificity (almost no false positives) but low sensitivity (high false negative rate). Where high sensitivity is needed, we offer a revised methodology for signature design which may designate that multiple signatures are required to detect all sequenced strains. We use this methodology to produce new signatures that are predicted to have higher sensitivity and specificity. Conclusions: We show that current methods for real-time PCR assay design have unacceptably low sensitivities for most clinical applications. Additionally, as new sequence data becomes available, old assays must be reassessed and redesigned. A standard protocol for both generating and assessing the quality of these assays is therefore of great value. Real-time PCR has the capacity to greatly improve clinical diagnostics. The improved assay design and evaluation methods presented herein will expedite adoption of this technique in the clinical lab.
Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus
Yeliz Genç, Reşit Özkanca and Yunus Bekdemir Wed, 20 Aug 2008 00:00:00 -0000
Background: Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S. aureus due to methicillin resistance. Methods: Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S. aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S. aureus ATCC 29213 was also tested. Results: The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S. aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S. aureus MRSAisolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. Conclusion: This study may help to suggest an alternative possible leading compound for development of new antimicrobial agents against MRSA and MSSA resistant S. aureus. It was also shown here that that clinical isolates of 50 S. aureus have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for S. aureus need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.
Sites:
Aloha Laboratories, Inc: Providing services to physicians, clinics, surgery centers and medical groups throughout the Pacific region. Contact and service details are given with an outline of cancer pathology. Honolulu, Hawaii.AmeriPath, Inc.: National provider of anatomic pathology services and dermatopathology in disease diagnosis for physicians, hospitals and clinical laboratories.
Avera Laboratory Network: A catalogue of available tests and a list of service centres are given with information on customer support. South Dakota.
BioHealth Diagnostics Laboratory: BioHealth is a leading innovator in laboratory testing and treatment methods for a wide range of conditions, evaluating hormones, immunity, digestion, and metabolism.
Blood-Check: Full service blood tests and health screening services
Cambridge Biomedical Research Group: High-quality reference laboratory providing esoteric tests. DesignerLab service guarantees clients new tests are operational within 90 days. Diagnostic Incubator helps academia and small business commercialize assays.
Cutting Edge: Provides dermatopatholgy services and includes a printable order form. Tigard, Oregon, USA.
Direct Laboratory Services, Inc: Blood tests and wellness screening tests for individuals who desire to stay healthy and fit.
Florida Hospital Cancer Institute: Florida Hospital Cancer Institute Clinical and Research Laboratories undertake clinical testing in hemostasis, thrombosis and molecular diagnostics; clinical research in heparin-induced thrombocytopenia, and basic research in blood coagulation and cancer metastasis
Gamma-Dynacare: Learn about Gamma-Dynacare Medical Laboratories and our extensive range of community, clinical trial, employee health and institutional laboratory services. Find information on our mission, values, role in the health care system and accomplishments.
Independent Histopathology Services: Providing services to the private and government health sectors. Details of staff, services and quality assurance standards are given with an outline of logistics. London, England.
Laboratory Medicine Consultants, Ltd.: Offering surgical pathology and cytology services. Staff, test and insurance information is provided with health advice and references. Las Vegas, Nevada.
Lakewood Pathology Associates: Providing global pathology services to hospitals, physicians and patients as well as consumer education on cervical cancer, Pap tests and other issues. Lakewood, New Jersey.
Lower Columbia Pathologists: Lower Columbia Pathologists; an anatomic pathology laboratory providing quality, timely, diagnostic test results to our clients in the fields of Nuclear Medicine, Histology, Cytology, Immunohistochemistry and Dermatopathology.
MDS Laboratory Services, Inc.: Clinical laboratory services in the United States and Canada. Staff profiles are provided with test information, reference ranges and a list of locations.
Midwest Hemostais and Thrombosis Laboratories, Inc.: Specialising in bleeding and thrombotic disorders. Test information, educational articles and symposium details. Muncie, Indiana.
Pathogenesys: Providing DNA analysis, immunohistochemistry and other pathology services for the pharmaceutical and biotechnology industries.
PhenoPath Laboratories: A national immunohistochemistry service in the United States. Clinical and research services are described and cases of interest are illustrated with photomicrographs.
Precision Pathology: Provides ooutpatient, surgical and clinical services, as well as cytopathology. Arvada, Colorado, USA.
Regional Medical Laboratories, Inc.: Regional Medical Laboratories, Inc. is an independent clinical laboratory that provides laboratory services to area physicians, hospitals, clinics, nursing homes, veterinarians, and occupational medicine throughout Southwest Michigan. Since 1950, we have served the laboratory needs of the greater...
San Diego Pathologists Medical Group, Inc: Details of services provided in anatomic pathology, cytology, histology, immunohistochemistry and research.
UniPath, LLC: UniPath is the largest Pathology Practice in the Rocky Mountain Region, with 25 pathologist physicians and supporting histotechnologists, cytotechnologists, management and other personnel.
Walter Reed Army Medical Center Pathology Department: A hospital-based laboratory offering a full range of clinical and anatomic services including electron microscopy, immunohistochemistry, transfusion medicine and autopsy services.
Weland Clinical Laboratories: Weland Clinical Laboratories, P.C., has been serving Eastern Iowa for thirty-five years. Weland Clinical Laboratories, P.C. is a full service pathologist owned and directed laboratory, operating five convenient locations. Weland's team of health care professionals is dedicated to providing the hi...
This directory is based on the Open Directory and may have been modified
