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Annals of Clinical Microbiology and Antimicrobials - Latest articles

Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococcuc aureus
Yeliz Genc, Resit Ozkanca and Yunus Bekdemir Wed, 20 Aug 2008 00:00:00 -0000
Background: Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential patogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S.aureus due to methicillin resistance. Methods: Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S.aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S.aureus ATCC 29213 was also tested. Results: The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S.aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S.aureus MRSA isolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. Conclusion: This study may help to suggest an alternative possible leading compounds for development of new antimicrobial agents against MRSA and MSSA resistant S.aureus. It was also shown here that that clinical isolates of 50 S.aureus have various resistance patterns against to four sulfonamide derivatives. It may also be emphasized here that in vitro antimicrobial susceptibility testing results for S.aureus species need standardization with further studies and it should also have a correlation with in vivo therapeutic response experiments.
Severe pulmonary tuberculosis complicating Ileocecal intussusception due to intestinal tuberculosis: a case report
Shigeki Nakamura, Katsunori Yanagihara, Koichi Izumikawa, Masafumi Seki, Hiroshi Kakeya, Yoshihiro Yamamoto, Yoshitugu Miyazaki, Naofumi Suyama and Shigeru Kohno Sun, 13 Jul 2008 00:00:00 -0000
Adult intussusception is a rare clinical entity that is most often caused by a tumor, such as a lipoma, adenoma, or malignant tumor. A case of adult intussusception due to intestinal tuberculosis of the ileocecal region is reported. There are few cases of intussusception due to intestinal tuberculosis.
In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay
Manimuthu Mani Sankar, Krishnamoorthy Gopinath, Roopak Singla and Sarman Singh Fri, 11 Jul 2008 00:00:00 -0000
Background: Non-tubercular mycobacteria (NTM) has not been given due attention till the recent epidemic of HIV. This has led to increasing interest of health care workers in their biology, epidemiology and drug resistance. However, timely detection and drug susceptibility profiling of NTM isolates are always difficult in resource poor settings like India. Furthermore, no standardized methodology or guidelines are available to reproduce the results with clinical concordance.ObjectiveTo find an alternative and rapid method for performing the drug susceptibility assay in a resource limited settings like India, we intended to evaluate the utility of Tetrazolium microplate assay (TEMA) in comparison with proportion method for reporting the drug resistance in clinical isolates of NTM. Methods: A total of fifty-five NTM isolates were tested for susceptibility against Streptomycin, Rifampicin, Ethambutol, Ciprofloxacin, Ofloxacin, Azithromycin, and Clarithromycin by TEMA and the results were compared with agar proportion method (APM). Results: Of the 55 isolates, 23 (41.8%) were sensitive to all the drugs and the remaining 32 (58.2%) were resistant to at least one drug. TEMA had very good concordance with APM except with minor discrepancies. Susceptibility results were obtained in the median of 5 to 9 days by TEMA. The NTM isolates were highly sensitive against Ofloxacin (98.18% sensitive) and Ciprofloxacin (90.09% sensitive). M. mucogenicum was sensitive only to Clarithromycin and resistant to all the other drugs tested. The concordance between TEMA and APM ranged between 96.4 – 100%. Conclusion: Tetrazolium Microplate Assay is a rapid and highly reproducible method. However, it must be performed only in tertiary level Mycobacteriology laboratories with proper bio-safety conditions.

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