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Statewide :: Pennsylvania :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", wecan help! Many job openings for physicians may be hidden and unavailable unless you knowwhere to
Statewide :: Virginia :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
Statewide :: Texas :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
pubmed: 0161-5505
Medical Effects of Ionizing Radiation.
Wong FC, Kim EE Related Articles Medical Effects of Ionizing Radiation. J Nucl Med. 2009 Nov 12; Authors: Wong FC, Kim EE PMID: 19910440 [PubMed - as supplied by publisher]
Imaging Vascular Endothelial Growth Factor (VEGF) Receptors in Turpentine-Induced Sterile Thigh Abscesses with Radiolabeled Single-Chain VEGF.
Levashova Z, Backer M, Backer JM, Blankenberg FG Related Articles Imaging Vascular Endothelial Growth Factor (VEGF) Receptors in Turpentine-Induced Sterile Thigh Abscesses with Radiolabeled Single-Chain VEGF. J Nucl Med. 2009 Nov 12; Authors: Levashova Z, Backer M, Backer JM, Blankenberg FG Angiogenesis plays a central role in the pathogenesis of chronic inflammatory disorders. Vascular endothelial growth factor (VEGF) and its receptors are the most important regulators of angiogenesis. We wished to determine whether labeled forms of single-chain VEGF (scVEGF) could be used to image VEGF receptors in a well-characterized model of sterile soft-tissue inflammation induced by intramuscular injection of turpentine. METHODS: Anesthetized adult male Swiss-Webster mice received a 20-muL intramuscular injection of turpentine into the right thigh. At 4, 7, or 10 d later, groups of 3-5 mice were injected via the tail vein with 50 mug of either scVEGF that had been site specifically labeled with Cy5.5 (scVEGF/Cy) or inactivated scVEGF/Cy (inVEGF/Cy) and then examined by fluorescence imaging. At 3, 4, 6, 7, 9, 10, or 12 d, additional groups of 3-5 mice were injected via the tail vein with 74-111 MBq of (99m)Tc-scVEGF (or (99m)Tc-inVEGF) and then examined by SPECT imaging. RESULTS: On days 3 through 10, both forms of scVEGF (scVEGF/Cy and (99m)Tc-scVEGF) showed significantly higher uptake (P < 0.05) in the right (abscessed) thigh than in the contralateral thigh (and higher uptake than the inactivated tracer). Peak uptake occurred on day 7 (3.67 +/- 1.79 [ratio of uptake in abscessed thigh to uptake in normal thigh, mean +/- SD] and 0.72 +/- 0.01 for scVEGF/Cy and inVEGF/Cy, respectively, and 3.49 +/- 1.22 and 1.04 +/- 0.41 for (99m)Tc-scVEGF and (99m)Tc-inVEGF, respectively) and slowly decreased thereafter. Autoradiography revealed peak tracer uptake in the thick irregular angiogenic rim of the abscess cavity on day 9 (5.83 x 10(-7) +/- 9.22 x 10(-8) and 5.85 x 10(-8) +/- 5.95 x 10(-8) percentage injected dose per pixel for (99m)Tc-scVEGF and (99m)Tc-inVEGF, respectively); in comparison, a thin circumscribed rim of uptake was seen with (99m)Tc-inVEGF. Immunostaining revealed that VEGFR-2 (VEGF receptor) colocalized with CD31 (endothelial cell marker) at all time points in the abscess rim, whereas F4/80 (macrophage) immunostaining reached a maximum at day 7 and decreased by day 10. CONCLUSION: The uptake of scVEGF in turpentine-induced abscesses was specific and directly related to VEGFR-2 expression in the neovasculature of the angiogenic rim. Peak tracer uptake coincided with maximum macrophage infiltration, suggesting that scVEGF imaging may be useful for the detection, localization, and monitoring of chronic inflammation in bone, joints, or soft tissues. PMID: 19910439 [PubMed - as supplied by publisher]
Endothelial Dysfunction in Diabetic Patients with Abnormal Myocardial Perfusion in the Absence of Epicardial Obstructive Coronary Artery Disease.
Djaberi R, Roodt JO, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW Related Articles Endothelial Dysfunction in Diabetic Patients with Abnormal Myocardial Perfusion in the Absence of Epicardial Obstructive Coronary Artery Disease. J Nucl Med. 2009 Nov 12; Authors: Djaberi R, Roodt JO, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. METHODS: Prospectively, 130 asymptomatic patients with diabetes mellitus underwent cardiovascular screening by coronary artery calcium (CAC) scoring, multislice CT coronary angiography, and myocardial perfusion imaging by SPECT. Multislice CT images were evaluated for the presence of obstructive epicardial CAD (>/=50% luminal narrowing). To quantify abnormal myocardial perfusion on SPECT images, we determined the summed stress score for each patient. The presence of abnormal myocardial perfusion was defined as a summed stress score of 3 or more. In addition, flow-mediated dilatation of the brachial artery, a marker of endothelial function, was determined using ultrasonography. RESULTS: In 35 patients (27%), obstructive epicardial CAD was observed on multislice CT, and these patients were excluded from further analysis. In the remaining 95 patients, abnormal myocardial perfusion was observed in 30 (32%) of patients. Flow-mediated dilatation was significantly lower in patients with abnormal myocardial perfusion (3.6% +/- 2.4%) than in those with normal myocardial perfusion (6.4% +/- 2.6%) (P < 0.001). Importantly, flow-mediated dilatation remained a significant predictor of the extent of abnormal myocardial perfusion after correction for cardiovascular risk factors and CAC score (P < 0.001). In contrast, no association was observed between nonobstructive plaque burden as reflected by CAC scores and extent of abnormal myocardial perfusion. CONCLUSION: In patients with diabetes mellitus, myocardial perfusion abnormalities in the absence of obstructive epicardial CAD are associated with endothelial dysfunction. PMID: 19910438 [PubMed - as supplied by publisher]
pubmed: 1532-6551
(11)C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium.
Fallavollita JA, Banas MD, Suzuki G, Dekemp RA, Sajjad M, Canty JM Related Articles (11)C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium. J Nucl Cardiol. 2009 Nov 10; Authors: Fallavollita JA, Banas MD, Suzuki G, Dekemp RA, Sajjad M, Canty JM BACKGROUND: Regional cardiac sympathetic nerve dysfunction develops in hibernating myocardium and may play a role in its association with sudden cardiac death. Interventions to improve cardiac function (i.e., revascularization) improve survival, but the potential reversibility of sympathetic nerve dysfunction remains unclear. METHODS AND RESULTS: Pigs (n = 11) were chronically instrumented with a proximal left anterior descending coronary artery (LAD) stenosis to produce hibernating myocardium. Prior to therapeutic interventions, there was LAD occlusion with collateral-dependent myocardium, reduced regional function (echocardiographic LAD wall-thickening 23% +/- 4% vs 83% +/- 6% in Remote, P < .001), and large defects in (11)C-meta-hydroxyephedrine (HED) PET (48% +/- 4% of LV area, 26% +/- 2% integrated reduction). Successful PCI or pravastatin therapy improved regional (LAD wall-thickening 23% +/- 4% to 42% +/- 6%, P < .05) and global LV function (fractional shortening 24% +/- 2% to 31% +/- 2%, P < .01), but did not alter regional HED uptake, retention, defect size, or defect severity. CONCLUSIONS: Despite significant functional improvement of hibernating myocardium as a result of PCI or pravastatin therapy, there were no changes in HED defect size or severity. Thus, inhomogeneity in myocardial sympathetic innervation persisted, and the lack of plasticity suggests that even in the absence of significant infarction, structural rather than functional defects are responsible for reduced myocardial norepinephrine uptake in chronic ischemic heart disease. PMID: 19902319 [PubMed - as supplied by publisher]
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Statewide :: Pennsylvania :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", wecan help! Many job openings for physicians may be hidden and unavailable unless you knowwhere to
Statewide :: Virginia :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
Statewide :: Texas :: The Doctor Job
Looking for a job in a big city? Even if you've heard that a market is "saturated", we can help! Many job openings for physicians may be hidden and unavailable unless you know where to look. An excellent
pubmed: 0161-5505
Medical Effects of Ionizing Radiation.
Wong FC, Kim EE Related Articles Medical Effects of Ionizing Radiation. J Nucl Med. 2009 Nov 12; Authors: Wong FC, Kim EE PMID: 19910440 [PubMed - as supplied by publisher]
Imaging Vascular Endothelial Growth Factor (VEGF) Receptors in Turpentine-Induced Sterile Thigh Abscesses with Radiolabeled Single-Chain VEGF.
Levashova Z, Backer M, Backer JM, Blankenberg FG Related Articles Imaging Vascular Endothelial Growth Factor (VEGF) Receptors in Turpentine-Induced Sterile Thigh Abscesses with Radiolabeled Single-Chain VEGF. J Nucl Med. 2009 Nov 12; Authors: Levashova Z, Backer M, Backer JM, Blankenberg FG Angiogenesis plays a central role in the pathogenesis of chronic inflammatory disorders. Vascular endothelial growth factor (VEGF) and its receptors are the most important regulators of angiogenesis. We wished to determine whether labeled forms of single-chain VEGF (scVEGF) could be used to image VEGF receptors in a well-characterized model of sterile soft-tissue inflammation induced by intramuscular injection of turpentine. METHODS: Anesthetized adult male Swiss-Webster mice received a 20-muL intramuscular injection of turpentine into the right thigh. At 4, 7, or 10 d later, groups of 3-5 mice were injected via the tail vein with 50 mug of either scVEGF that had been site specifically labeled with Cy5.5 (scVEGF/Cy) or inactivated scVEGF/Cy (inVEGF/Cy) and then examined by fluorescence imaging. At 3, 4, 6, 7, 9, 10, or 12 d, additional groups of 3-5 mice were injected via the tail vein with 74-111 MBq of (99m)Tc-scVEGF (or (99m)Tc-inVEGF) and then examined by SPECT imaging. RESULTS: On days 3 through 10, both forms of scVEGF (scVEGF/Cy and (99m)Tc-scVEGF) showed significantly higher uptake (P < 0.05) in the right (abscessed) thigh than in the contralateral thigh (and higher uptake than the inactivated tracer). Peak uptake occurred on day 7 (3.67 +/- 1.79 [ratio of uptake in abscessed thigh to uptake in normal thigh, mean +/- SD] and 0.72 +/- 0.01 for scVEGF/Cy and inVEGF/Cy, respectively, and 3.49 +/- 1.22 and 1.04 +/- 0.41 for (99m)Tc-scVEGF and (99m)Tc-inVEGF, respectively) and slowly decreased thereafter. Autoradiography revealed peak tracer uptake in the thick irregular angiogenic rim of the abscess cavity on day 9 (5.83 x 10(-7) +/- 9.22 x 10(-8) and 5.85 x 10(-8) +/- 5.95 x 10(-8) percentage injected dose per pixel for (99m)Tc-scVEGF and (99m)Tc-inVEGF, respectively); in comparison, a thin circumscribed rim of uptake was seen with (99m)Tc-inVEGF. Immunostaining revealed that VEGFR-2 (VEGF receptor) colocalized with CD31 (endothelial cell marker) at all time points in the abscess rim, whereas F4/80 (macrophage) immunostaining reached a maximum at day 7 and decreased by day 10. CONCLUSION: The uptake of scVEGF in turpentine-induced abscesses was specific and directly related to VEGFR-2 expression in the neovasculature of the angiogenic rim. Peak tracer uptake coincided with maximum macrophage infiltration, suggesting that scVEGF imaging may be useful for the detection, localization, and monitoring of chronic inflammation in bone, joints, or soft tissues. PMID: 19910439 [PubMed - as supplied by publisher]
Endothelial Dysfunction in Diabetic Patients with Abnormal Myocardial Perfusion in the Absence of Epicardial Obstructive Coronary Artery Disease.
Djaberi R, Roodt JO, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW Related Articles Endothelial Dysfunction in Diabetic Patients with Abnormal Myocardial Perfusion in the Absence of Epicardial Obstructive Coronary Artery Disease. J Nucl Med. 2009 Nov 12; Authors: Djaberi R, Roodt JO, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. METHODS: Prospectively, 130 asymptomatic patients with diabetes mellitus underwent cardiovascular screening by coronary artery calcium (CAC) scoring, multislice CT coronary angiography, and myocardial perfusion imaging by SPECT. Multislice CT images were evaluated for the presence of obstructive epicardial CAD (>/=50% luminal narrowing). To quantify abnormal myocardial perfusion on SPECT images, we determined the summed stress score for each patient. The presence of abnormal myocardial perfusion was defined as a summed stress score of 3 or more. In addition, flow-mediated dilatation of the brachial artery, a marker of endothelial function, was determined using ultrasonography. RESULTS: In 35 patients (27%), obstructive epicardial CAD was observed on multislice CT, and these patients were excluded from further analysis. In the remaining 95 patients, abnormal myocardial perfusion was observed in 30 (32%) of patients. Flow-mediated dilatation was significantly lower in patients with abnormal myocardial perfusion (3.6% +/- 2.4%) than in those with normal myocardial perfusion (6.4% +/- 2.6%) (P < 0.001). Importantly, flow-mediated dilatation remained a significant predictor of the extent of abnormal myocardial perfusion after correction for cardiovascular risk factors and CAC score (P < 0.001). In contrast, no association was observed between nonobstructive plaque burden as reflected by CAC scores and extent of abnormal myocardial perfusion. CONCLUSION: In patients with diabetes mellitus, myocardial perfusion abnormalities in the absence of obstructive epicardial CAD are associated with endothelial dysfunction. PMID: 19910438 [PubMed - as supplied by publisher]
pubmed: 1532-6551
(11)C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium.
Fallavollita JA, Banas MD, Suzuki G, Dekemp RA, Sajjad M, Canty JM Related Articles (11)C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium. J Nucl Cardiol. 2009 Nov 10; Authors: Fallavollita JA, Banas MD, Suzuki G, Dekemp RA, Sajjad M, Canty JM BACKGROUND: Regional cardiac sympathetic nerve dysfunction develops in hibernating myocardium and may play a role in its association with sudden cardiac death. Interventions to improve cardiac function (i.e., revascularization) improve survival, but the potential reversibility of sympathetic nerve dysfunction remains unclear. METHODS AND RESULTS: Pigs (n = 11) were chronically instrumented with a proximal left anterior descending coronary artery (LAD) stenosis to produce hibernating myocardium. Prior to therapeutic interventions, there was LAD occlusion with collateral-dependent myocardium, reduced regional function (echocardiographic LAD wall-thickening 23% +/- 4% vs 83% +/- 6% in Remote, P < .001), and large defects in (11)C-meta-hydroxyephedrine (HED) PET (48% +/- 4% of LV area, 26% +/- 2% integrated reduction). Successful PCI or pravastatin therapy improved regional (LAD wall-thickening 23% +/- 4% to 42% +/- 6%, P < .05) and global LV function (fractional shortening 24% +/- 2% to 31% +/- 2%, P < .01), but did not alter regional HED uptake, retention, defect size, or defect severity. CONCLUSIONS: Despite significant functional improvement of hibernating myocardium as a result of PCI or pravastatin therapy, there were no changes in HED defect size or severity. Thus, inhomogeneity in myocardial sympathetic innervation persisted, and the lack of plasticity suggests that even in the absence of significant infarction, structural rather than functional defects are responsible for reduced myocardial norepinephrine uptake in chronic ischemic heart disease. PMID: 19902319 [PubMed - as supplied by publisher]
Sites:
American Board of Nuclear Medicine: The Board advances the health of the public through the establishment and maintenance of standards of training, and education, and the qualification of physicians rendering nuclear medicine services to the people of the United States.American College of Nuclear Physicians: A trade association that represents the interests of nuclear medicine physicians before legislative and regulatory bodies, other medical organizations, the media and general public.
American Society of Nuclear Cardiology: The American Society of Nuclear Cardiology is a professional medical society whose mission is to foster optimal delivery of nuclear cardiology services through professional education and training, the development of clinical guidelines, and the promotion of research.
Australian and New Zealand Society of Nuclear Medicine: About their history, branches, as well as their meetings and publications. Membership forms online.
British Nuclear Medicine Society: The British Nuclear Medicine Society web site gives information on medical events, adverse drug reactions and all other relevant information on nuclear medicine
Clinical Nuclear Medicine: Published monthly, with free abstracts, archived articles, and supscription details.
CNMT: Specializes in finding nuclear medicine jobs for nuclear medicine technologists.
CNR Nuclear Medicine Center: Research institute of the Italian National Research Council, focusing on diagnostic imaging of the central nervous system.
DrSpectScan.com: brain spect scanning and analysis, including before,and after any type of therapy for brain dysfunction. (analyses will be extended to the developing contributionsthat will come via PET and fMRI scanning), all modalities of bra...
European Association of Nuclear Medicine: European Association of Nuclear Medicine, Hollandstrasse 14 / Mezzanine, A-1020 Vienna, Austria Phone, +43 -1 - 2 12 80 30, Fax +43 -1 - 2 12 80 309
Hellenic Society of Nuclear Medicine: Based in Thessaloniki, Greece. Includes the Hellenic Journal of Nuclear Medicine.
History of Positron Imaging: A HISTORY OF POSITRON IMAGING
How Stuff Works: Nuclear Medicine: Nuclear materials get used in many forms of nuclear medicine -- everything from PET scans to chemotherapy uses them! Learn how nuclear medicine works!
Imaginis - Nuclear medicine imaging: Award-winning, breast cancer information and news resource. Imaginis also covers related breast cancer health topics such as hormone replacement therapy (HRT), heart disease, multiple sclerosis, osteoporosis, cervical cancer, and ovarian cancer, as well as, extensive information about medical pr...
Joint Program in Nuclear Medicine: Information on this program from Harvard Medical School.
Nuclear Imaging Westmead: Nuclear Imaging Westmead provides a full range of Nuclear imaging services including traditional radiology and advanced imaging to the health care sector.
Nuclear Medicine Communications: Monthly journal of the BNMS publishing research and clinical work in all areas of nuclear medicine. Submission guidelines and subscription details available.
Nuclear Medicine Information: This site provides information and breaking news about nuclear medicine, PET and related technologies.
Nuclear Medicine jobs: Nuclear Medicine jobs are listed at Physician Employment. You may register to be automatically updated when new jobs are listed.
Nuclear Medicine on the Net: This site features case studies and interactive case forums amongst other physician information resources, and gives a brief history of the topic for the layperson. [Uses Frames]
Nuclear Medicine Research Council: Provides a topical introduction, as well as its use in treating disease and the production and use of radioisotopes.
Nuclear Medicine Technology Resource: Nuclear Medicine Technology Resource WebSite
Positron Emission Tomography: Current and accurate information for patients about Nuclear Medicine, PET. Learn what you might experience, how to prepare for the exam, benefits, risks and more.
Positron Emission Tomography in oncology: Information is provided about the use of dynamic PET, including compartment modeling and parametric imaging, for cancer therapy management.
Radiation Emergency Assistance Center/Training Site: REAC/TS is available 24/7 to provide emergency medical services or advice/consultation related to incidents involving radiological or nuclear materials.
RadiologyInfo: Nuclear Medicine procedure menu
Society of Nuclear Medicine: An international scientific and professional organization founded in 1954 to promote the science, technology and practical application of nuclear medicine.
University of Kansas - Nuclear Medicine: Details about their program and equipment, radiopharamaceutics, quality control, radioimmunoassay and PET. Large collection of clinical and research teaching files.
This directory is based on the Open Directory and may have been modified
