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Permanent Neurology Job in Call for More Information Illinois with Medical Search International
A prestigious medical center located in a beautiful Metro community in Illinois is seeking a BC/BE Neurosurgeon to joint their specialty group. State license is preferred but eligibility is acceptable.
Permanent Neurology Job in Call for More Information Washington with Medical Search International
A prestigious 200+ bed medical center located in the greater Seattle area is seeking a BC/BE Neurosurgeon to join their specialty group. The practice consists of 2 surgeons with plans to expand to 4
Permanent Neurology Job in Call for More Information Texas with Medical Search International
A busy medical center located in the Dallas area is seeking a BC/BE Neurosurgeon to join their multi-specialty group. State license is preferred but eligibility is acceptable. Residents and fellows are
Archives of Neurology recent issues
ORIGINAL CONTRIBUTION: Treatment of Neuromyelitis Optica With Rituximab: Retrospective Analysis of 25 Patients
Jacob, A., Weinshenker, B. G., Violich, I., McLinskey, N., Krupp, L., Fox, R. J., Wingerchuk, D. M., Boggild, M., Constantinescu, C. S., Miller, A., De Angelis, T., Matiello, M., Cree, B. A. C. Mon, 08 Sep 2008 00:00:00 -0000
Background Neuromyelitis optica (NMO) is an uncommon, life-threatening inflammatory demyelinating disorder. Recently, much has become known about its immunopathogenesis. However, optimal treatments, with expected outcomes, have not been established.Objective To evaluate the use and efficacy of rituximab for treating NMO.Design Retrospective multicenter case series of NMO patients treated with rituximab.Setting Seven tertiary medical centers in the United States and England.Patients Twenty-five patients (including 2 children), 23 of whom experienced relapses despite use of other drugs before rituximab. Extended follow-up of 7 previously reported patients is included.Interventions Infusions of rituximab at median intervals of 8 months.Main Outcome Measures Annualized relapse rate and disability (expressed as Expanded Disability Status Scale score).Results At a median follow-up of 19 months, the median annualized posttreatment relapse rate was lower than the pretreatment rate (0 [range 0-3.2] vs 1.7 [range, 0.5-5] relapses, P < .001). Disability improved or stabilized in 20 of 25 patients (80%, P = .02). Two patients died during the follow-up period, 1 owing to a brainstem relapse and 1 owing to suspected septicemia. Infections were reported in 20% of patients.Conclusions In NMO, treatment with rituximab appears to reduce the frequency of attacks, with subsequent stabilization or improvement in disability.Published online September 8, 2008 (doi:10.1001/archneur.65.11.noc80069).
ORIGINAL CONTRIBUTION: Assessment of {beta}-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11-Labeled Pittsburgh Compound B
Leinonen, V., Alafuzoff, I., Aalto, S., Suotunen, T., Savolainen, S., Nagren, K., Tapiola, T., Pirttila, T., Rinne, J., Jaaskelainen, J. E., Soininen, H., Rinne, J. O. Mon, 11 Aug 2008 00:00:00 -0000
Objective To compare carbon 11–labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens.Design Cross-sectional study of [11C]PiB PET findings in patients with or without β-amyloid (Aβ) aggregates in frontal cortical biopsy specimens.Setting Two university hospitals in Finland.Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Aβ aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus.Interventions [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests.Main Outcome Measures Immunohistochemical evaluation for Aβ aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET.Results In patients with Aβ aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P < .05) in the frontal, parietal, and lateral temporal cortices and in the striatum as compared with the patients without frontal Aβ deposits.Conclusions Our study supports the use of noninvasive [11C]PiB PET in the assessment of Aβ deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.Published online August 11, 2008 (doi:10.1001/archneur.65.10.noc80013).
ABOUT THIS JOURNAL: About This Journal
Mon, 08 Sep 2008 00:00:00 -0000
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Permanent Neurology Job in Call for More Information Illinois with Medical Search International
A prestigious medical center located in a beautiful Metro community in Illinois is seeking a BC/BE Neurosurgeon to joint their specialty group. State license is preferred but eligibility is acceptable.
Permanent Neurology Job in Call for More Information Washington with Medical Search International
A prestigious 200+ bed medical center located in the greater Seattle area is seeking a BC/BE Neurosurgeon to join their specialty group. The practice consists of 2 surgeons with plans to expand to 4
Permanent Neurology Job in Call for More Information Texas with Medical Search International
A busy medical center located in the Dallas area is seeking a BC/BE Neurosurgeon to join their multi-specialty group. State license is preferred but eligibility is acceptable. Residents and fellows are
Archives of Neurology recent issues
ORIGINAL CONTRIBUTION: Treatment of Neuromyelitis Optica With Rituximab: Retrospective Analysis of 25 Patients
Jacob, A., Weinshenker, B. G., Violich, I., McLinskey, N., Krupp, L., Fox, R. J., Wingerchuk, D. M., Boggild, M., Constantinescu, C. S., Miller, A., De Angelis, T., Matiello, M., Cree, B. A. C. Mon, 08 Sep 2008 00:00:00 -0000
Background Neuromyelitis optica (NMO) is an uncommon, life-threatening inflammatory demyelinating disorder. Recently, much has become known about its immunopathogenesis. However, optimal treatments, with expected outcomes, have not been established.Objective To evaluate the use and efficacy of rituximab for treating NMO.Design Retrospective multicenter case series of NMO patients treated with rituximab.Setting Seven tertiary medical centers in the United States and England.Patients Twenty-five patients (including 2 children), 23 of whom experienced relapses despite use of other drugs before rituximab. Extended follow-up of 7 previously reported patients is included.Interventions Infusions of rituximab at median intervals of 8 months.Main Outcome Measures Annualized relapse rate and disability (expressed as Expanded Disability Status Scale score).Results At a median follow-up of 19 months, the median annualized posttreatment relapse rate was lower than the pretreatment rate (0 [range 0-3.2] vs 1.7 [range, 0.5-5] relapses, P < .001). Disability improved or stabilized in 20 of 25 patients (80%, P = .02). Two patients died during the follow-up period, 1 owing to a brainstem relapse and 1 owing to suspected septicemia. Infections were reported in 20% of patients.Conclusions In NMO, treatment with rituximab appears to reduce the frequency of attacks, with subsequent stabilization or improvement in disability.Published online September 8, 2008 (doi:10.1001/archneur.65.11.noc80069).
ORIGINAL CONTRIBUTION: Assessment of {beta}-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11-Labeled Pittsburgh Compound B
Leinonen, V., Alafuzoff, I., Aalto, S., Suotunen, T., Savolainen, S., Nagren, K., Tapiola, T., Pirttila, T., Rinne, J., Jaaskelainen, J. E., Soininen, H., Rinne, J. O. Mon, 11 Aug 2008 00:00:00 -0000
Objective To compare carbon 11–labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) findings in patients with and without Alzheimer disease lesions in frontal cortical biopsy specimens.Design Cross-sectional study of [11C]PiB PET findings in patients with or without β-amyloid (Aβ) aggregates in frontal cortical biopsy specimens.Setting Two university hospitals in Finland.Patients Ten patients who had undergone intraventricular pressure monitoring with a frontal cortical biopsy (evaluated for Aβ aggregates and hyperphosphorylated tau) for suspected normal-pressure hydrocephalus.Interventions [11C]PiB PET and evaluation for cognitive impairment using a battery of neuropsychological tests.Main Outcome Measures Immunohistochemical evaluation for Aβ aggregates and hyperphosphorylated tau in the frontal cortical biopsy specimen and [11C]PiB PET.Results In patients with Aβ aggregates in the frontal cortical biopsy specimen, PET imaging revealed higher [11C]PiB uptake (P < .05) in the frontal, parietal, and lateral temporal cortices and in the striatum as compared with the patients without frontal Aβ deposits.Conclusions Our study supports the use of noninvasive [11C]PiB PET in the assessment of Aβ deposition in the brain. Large prospective studies are required to verify whether [11C]PiB PET will be a diagnostic aid, particularly in early Alzheimer disease.Published online August 11, 2008 (doi:10.1001/archneur.65.10.noc80013).
ABOUT THIS JOURNAL: About This Journal
Mon, 08 Sep 2008 00:00:00 -0000
Sites:
Family Practice Notebook: Neurology: Covers Autonomic, Cerebellum, Chorea, Cranial Nerve, Cognitive, CSF, Demyelinating, Disability, Examination, Headache, Level of Consciousness, Motor, Procedure, Seizure, Sensory, Symptom Evaluation and Tremor. Related chapters from other specialties include Cardiovascular, Dermatology, Ophthalmo...Foundation for Education and Research in Neurological Emergencies: Information about this non-profit organization for improving the care of Emergency Department patients with neurological emergencies. Offers free educational courses and sponsors research for Emergency Physicians.
General Practice Notebook - Neurology: Coverage of this medical specialty.
HowStuffWorks: How Your Brain Works: Every animal you can think of -- mammals, birds, reptiles, fish, amphibians -- all have brains. But the human brain is unique. It gives us the power to think, plan, speak, imagine... Find out all about this amazing organ.
Institute for Nerve Medicine: Presenting information on disorders of the cranial, spinal and peripheral nerves. Includes illustrated descriptions of treatment options.
Iowa Neuroradiology Library: Department of Neurology, University of Iowa Hospitals and Clinics. Radiology teaching file.
National Institute of Neurological Disorders and Stroke: An NIH site with research and clinical information on disorders of the brain and nervous system.
Neuroconsult: Information resource on Clinical Neurology. Covering areas such as alzheimers, epilepsy, migraine, motor neurone, multiple sclerosis, pain, parkinsons, schizophrenia, and stroke.
NeuroExam.com: neuroexam.com is an interactive online guide to the neurologic examination, with video demonstrations. It is a companion to 'The NeuroExam Video' and 'Neuroanatomy Through Clinical Cases', both by Hal Blumenfeld
Neurological Teaching Videos: Digital video of the neurologic exam [Online registration, (free) required] by Wright State University.
Neurology Channel: NeurologyChannel is a comprehensive resource for seizures, stroke, coma, Alzheimer's, headaches, migraines, Parkinson's, and other brain and nervous system disorders. Features patient forum and neurologist search.
Neurology in Clinical Practice, 3e: An online professional neurology reference.
Neurology Jobs: Physician employment opportunities for all specialties in North America.
Neurology-Info.net: Information about the nervous system in health and disease. Part of the ALtruis Biomedical Network.
NeurologyLinx: Neurologist keep current with free medical news and daily newsletters. NeurologyLinx and MDLinx aggregates the most current medical journal news and research from premier medical and healthcare journals and news sources. Comprehensive, specialized content updated every day on the web and in email...
Neurosciences on the Internet: Neurosciences on the Internet contains a searchable and browsable index of neuroscience resources available on the World Wide Web and other parts of the Internet. Neurobiology, neurology, neurosurgery, psychiatry, psychology, cognitive science sites and information on human neurological diseases...
Oregon Nerve Center: The Oregon Nerve Center is a leading center for research in the field of neurology.
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