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pubmed: 0001-5555

Facial purpura and scrotal swelling: a quiz. Henoch-Schönlein purpura.
Mizuashi M, Okuyama R, Matsumura N, Sugisaki K, Aiba S Related Articles Facial purpura and scrotal swelling: a quiz. Henoch-Schönlein purpura. Acta Derm Venereol. 2009;89(5):549-50 Authors: Mizuashi M, Okuyama R, Matsumura N, Sugisaki K, Aiba S PMID: 19734997 [PubMed - indexed for MEDLINE]

Latest Issue of American Journal of Clinical Dermatology

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Archives of Dermatological Research

Apolipoprotein ε4 allele is associated with psoriasis severity
Thu, 12 Nov 2009 18:38:38 -0000
Abstract  Many reports provided strong evidence of the influence of genetic factors in the pathogenesis of psoriasis (Ps). A higher prevalence of lipid disorders in psoriatic patients has been reported. Because apolipoprotein E (apoE) is involved in lipid metabolism, APOE gene variants could be candidates to influence Ps-risk. However, data about the potential influence of the APOE genotypes in Ps are inconclusive. Our objective was to investigate the relationship between the common APOE-ε2/ε3/ε4 variation and Ps in a Caucasian population. Our study involved 331 unrelated Ps-patients and 400 healthy controls. Patients and controls were genotyped for the APOE-ε2/ε3/ε4 polymorphism, and allele and genotype frequencies were statistically compared between the two groups and between patients according to disease severity. Mean lipid values were also compared between the APOE genotypes. Allele and genotype frequencies did not differ between patients and controls. APOE-ε4 carriers were significantly more frequent in patients with severe Ps compared to controls (P = 0.003) and to non-severe Ps (P = 0.017). No significant difference in mean lipid values was found between the APOE genotypes. The APOE-ε4 allele could be a risk factor for developing a severe form of psoriasis. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00403-009-1002-2Authors Pablo Coto-Segura, Hospital Universitario Central de Asturias (HUCA) Dermatology II Department Celestino Villamil s/n 33006 Oviedo SpainEliecer Coto, HUCA Molecular Genetics Department Oviedo SpainVictoria Alvarez, HUCA Molecular Genetics Department Oviedo SpainBlanca Morales, HUCA Molecular Genetics Department Oviedo SpainJavier Soto-Sánchez, Hospital Universitario Central de Asturias (HUCA) Dermatology II Department Celestino Villamil s/n 33006 Oviedo SpainA. I. Corao, HUCA Molecular Genetics Department Oviedo SpainJorge Santos-Juanes, Hospital Universitario Central de Asturias (HUCA) Dermatology II Department Celestino Villamil s/n 33006 Oviedo Spain Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696

BMC Dermatology - Latest Articles

Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study.
Niyati MukherjeeDean MorrellMadeleine DuvicPaul StewartLowell Goldsmith Thu, 12 Nov 2009 00:00:00 -0000
Background: Little evidence exists to guide treatment of alopecia areata (AA). The current practices in treatment of children compared to adults and of progressive stages of hair loss are unknown. The objective of this study was to examine the current practices of southeastern United States dermatologists for the treatment of AA. Methods: Dermatologists were sent anonymous questionnaires regarding their treatment practices by mail. Respondents' frequencies of treatment in children compared to adults and in patchy hair loss compared to widespread hair loss were compared with Wilcoxon signed-ranks tests and Friedman tests. As a secondary source, the National Alopecia Areata Registry (NAAR) database was analyzed for patients' treatment histories. Results: Survey results suggested that dermatologists recommend treatment less frequently for children than adults and for more advanced hair loss. NAAR data confirmed that offering no treatment for AA is relatively common. Conclusions: Dermatologists' treatment of AA is inconsistent. A stronger evidence base will provide more consistent treatment options.

Dermatology : Last 20 articles

Incidence of Auto-Immune Pemphigus in the Midi-Pyrénées Region in 2002--2006
Sat, 21 Nov 2009 00:00:00 +0100
Dermatology (DOI:10.1159/000261503)

pubmed: 1167-1122

Asymmetric periflexural exanthema associated with HHV7 infection.
Ali AA, Farhi D, Maricourt SD, Dupin N Related Articles Asymmetric periflexural exanthema associated with HHV7 infection. Eur J Dermatol. 2009 Nov 17; Authors: Ali AA, Farhi D, Maricourt SD, Dupin N PMID: 19919914 [PubMed - as supplied by publisher]

Exogenous Dermatology : Last 20 articles

Author Index Vol. 3, No. 4, 2004
Tue, 31 Jan 2006 00:00:00 +0100
Exog Dermatol 2004;3:201-202 (DOI:10.1159/000091311)

Expert Reviews: Expert Review of Dermatology: Table of Contents

Anti-inflammatory drugs for metastasizing  melanoma
info@expert-reviews.com (Vladislava O Melnikova et al) Mon, 12 Oct 2009 13:31:06 -0000
Expert Review of Dermatology , October 2009, Vol. 4, No. 5, Pages 431-433.

pubmed: 0022-202X

The Suppressor of Cytokine Signaling (SOCS)-3 Determines Keratinocyte Proliferative and Migratory Potential during Skin Repair.
Linke A, Goren I, Bösl MR, Pfeilschifter J, Frank S Related Articles The Suppressor of Cytokine Signaling (SOCS)-3 Determines Keratinocyte Proliferative and Migratory Potential during Skin Repair. J Invest Dermatol. 2009 Nov 19; Authors: Linke A, Goren I, Bösl MR, Pfeilschifter J, Frank S Recently, the suppressor of cytokine signaling (SOCS)-3 has been shown to be expressed in disturbed wound margin epithelia during diabetes-impaired wound healing in mice. To functionally connect a potential contribution of SOCS-3 expression to the control of wound keratinocyte behavior in skin repair, we created a transgenic mouse (tsgn-K5/SOCS3) overexpressing SOCS-3 in keratinocytes using the bovine keratin 5 promoter. Tsgn-K5/SOCS3 mice showed a constitutive expression of SOCS-3 in the basal layer of skin epidermis. Keratinocytes of tsgn-K5/SOCS3 mice showed full inhibition of signal transducer and activator of transcription (STAT)-3 phosphorylation. Tsgn-K5/SOCS3 keratinocytes also showed a strong inhibition of migratory and proliferative potential in vitro. In addition, tsgn-K5/SOCS3 keratinocytes co-expressed the differentiation marker loricrin in the basal layer of nonwounded skin in vivo. Upon wounding, wound tissues of tsgn-K5/SOCS3 mice showed an impairment of wound closure characterized by strongly atrophied wound margin epithelia. Atrophied epithelia of tsgn-K5/SOCS3 mice exhibited a marked reduction in proliferating cells and reduced total keratinocyte numbers. In summary, this study suggests that the presence of SOCS-3 in keratinocytes strongly disturbs epithelial repair of cutaneous wounds by interfering with keratinocyte proliferation and migration.Journal of Investigative Dermatology advance online publication, 19 November 2009; doi:10.1038/jid.2009.344. PMID: 19924142 [PubMed - as supplied by publisher]

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