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Archives of Dermatology current issue
ABOUT THIS JOURNAL: About This Journal
Mon, 20 Oct 2008 00:00:00 -0000
PubMed: 0001-5555
A contribution to the treatment of chronic urticaria and Quincke's oedema.
TARRAS-WAHLBERG B Related Articles A contribution to the treatment of chronic urticaria and Quincke's oedema. Acta Derm Venereol. 1948;28(4):352-6 Authors: TARRAS-WAHLBERG B PMID: 18891994 [PubMed - indexed for MEDLINE]
Latest Issue of American Journal of Clinical Dermatology
Acknowledgment
Adis International Limited,
The American Journal of Dermatopathology - Current Table Of Contents
Cutaneous and Superficial Soft Tissue Lesions Associated With Albright Hereditary Osteodystrophy: Clinicopathological and Molecular Genetic Study of 4 Cases, Including a Novel Mutation of the GNAS Gene.
Page: 417DOI: 10.1097/DAD.0b013e318180ec0eAuthors: Kacerovska, Denisa MD, PhD *; Nemcova, Jana MSc *; Pomahacova, Renata MD +; Michal, Michal MD *++; Kazakov, Dmitry V MD, PhD *
Archives of Dermatological Research
CD4+CD25+ regulatory T cells in human lupus erythematosus
Thu, 06 Nov 2008 00:34:06 -0000
Abstract Natural CD4+CD25+ regulatory T cells (Treg) show a potent immunosuppressive function and contribute to immunologic self-tolerance by suppressing potentially auto-reactive T cells. Depletion of these cells leads to the induction of severe autoimmune diseases in animal models; more recently, several studies have also reported an impairment of Treg number and/or function in various human autoimmune diseases. For example, aberrant numbers of circulating CD4+CD25+ Treg have been seen in patients with type I diabetes, mycosis fungoides, graft-versus-host-reaction, and rheumatoid arthritis. Moreover, increased numbers of functionally active CD4+CD25+ Treg have been detected in the synovial fluid of patients with rheumatoid arthritis. In systemic lupus erythematosus (SLE), conflicting data on the role of CD4+CD25+ Treg in human autoimmune diseases have been presented in the literature. Decreased numbers of peripheral blood Treg have been reported by most studies on SLE patients with active disease, but non-impaired or even increased CD4+CD25+ Treg numbers have also been described. In addition, both deficient and normal suppressive capacity of isolated Treg have been observed in SLE. Analysis of CD4+FoxP3+ Treg in skin lesions of patients with a primarily cutaneous manifestation of the disease showed a significant reduction in cell numbers as compared to other inflammatory skin diseases, suggesting the importance of analyzing Treg numbers in the affected tissue. In this review, we discuss the role of CD4+CD25+ Treg in autoimmunity and recent published data on SLE. Furthermore, we highlight the need for additional studies that address specific gaps of knowledge regarding the pathophysiological mechanisms as well as the identification of future therapeutic strategies for autoimmune diseases. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00403-008-0891-9Authors Annegret Kuhn, German Cancer Research Center Division of Immunogenetics, Tumor Immunology Program Heidelberg GermanyStefan Beissert, Westfälische Wilhelms-University Muenster Department of Dermatology Von-Esmarch-Strasse 58 48149 Muenster GermanyPeter H. Krammer, German Cancer Research Center Division of Immunogenetics, Tumor Immunology Program Heidelberg Germany Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest articles
Assessment of a new questionnaire for self-reported sun sensitivity in an occupational skin cancer screening program
Jurgen Tacke, Jens Dietrich, Beatrix Steinebrunner and Antonius Reifferscheid Fri, 24 Oct 2008 00:00:00 -0000
Background: Sun sensitivity of the skin is a risk factor for the development of cutaneous melanoma and other skin cancers. Epidemiological studies on causal factors for the development of melanoma must control for sun sensitivity as a confounder. A standardized instrument for measuring sun sensitivity has not been established yet. It is assumed that many studies show a high potential of residual confounding for sun sensitivity. In the present study, a new questionnaire for the assessment of self-reported sun sensitivity is administered and examined. Methods: Prior to an occupational skin cancer screening program, the 745 participating employees were asked to fill in a questionnaire for self-assessment of sun sensitivity. The questionnaire was developed by experts of the working group "Round Table Sunbeds" (RTS) to limit the health hazards of sunbed use in Germany. A sun sensitivity score (RTS-score) was calculated using 10 indicators. The internal consistency of the questionnaire and the agreement with other methods (convergent validity) were examined. Results: The RTS-score was calculated for 655 study participants who were 18 to 65 years of age. The correlation of the items among each other was between 0.12 and 0.62. The items and the RTS-score correlated between 0.46 and 0.77. The internal consistency showed a reliability coefficient of 0.82 (Cronbach`s alpha). The comparison with the Fitzpatrick classification, the prevailing standard, was possible in 617 cases with a rank correlation of rs=0.65. The categorization of the RTS-score in four risk groups showed correct classification to the four skin types of Fitzpatrick in 75 % of cases. Other methods for the assessment of sun sensitivity displayed varying agreements with the RTS-score. Conclusion: The RTS questionnaire showed a sufficient internal consistency. There is a good convergent validity between the RTS-score and the Fritzpatrick classification avoiding shortcomings of the prevailing standard. The questionnaire represents a simple, reliable and valid instrument for the assessment of sun sensitivity. It can be used in epidemiological studies as well as in skin cancer prevention programs. Further development and standardization of sun sensitivity assessments is necessary to strengthen the evidence of epidemiological studies on causal factors of melanoma and other skin cancers.
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ABOUT THIS JOURNAL: About This Journal
Mon, 20 Oct 2008 00:00:00 -0000
PubMed: 0001-5555
A contribution to the treatment of chronic urticaria and Quincke's oedema.
TARRAS-WAHLBERG B Related Articles A contribution to the treatment of chronic urticaria and Quincke's oedema. Acta Derm Venereol. 1948;28(4):352-6 Authors: TARRAS-WAHLBERG B PMID: 18891994 [PubMed - indexed for MEDLINE]
Latest Issue of American Journal of Clinical Dermatology
Acknowledgment
Adis International Limited,
The American Journal of Dermatopathology - Current Table Of Contents
Cutaneous and Superficial Soft Tissue Lesions Associated With Albright Hereditary Osteodystrophy: Clinicopathological and Molecular Genetic Study of 4 Cases, Including a Novel Mutation of the GNAS Gene.
Page: 417DOI: 10.1097/DAD.0b013e318180ec0eAuthors: Kacerovska, Denisa MD, PhD *; Nemcova, Jana MSc *; Pomahacova, Renata MD +; Michal, Michal MD *++; Kazakov, Dmitry V MD, PhD *
Archives of Dermatological Research
CD4+CD25+ regulatory T cells in human lupus erythematosus
Thu, 06 Nov 2008 00:34:06 -0000
Abstract Natural CD4+CD25+ regulatory T cells (Treg) show a potent immunosuppressive function and contribute to immunologic self-tolerance by suppressing potentially auto-reactive T cells. Depletion of these cells leads to the induction of severe autoimmune diseases in animal models; more recently, several studies have also reported an impairment of Treg number and/or function in various human autoimmune diseases. For example, aberrant numbers of circulating CD4+CD25+ Treg have been seen in patients with type I diabetes, mycosis fungoides, graft-versus-host-reaction, and rheumatoid arthritis. Moreover, increased numbers of functionally active CD4+CD25+ Treg have been detected in the synovial fluid of patients with rheumatoid arthritis. In systemic lupus erythematosus (SLE), conflicting data on the role of CD4+CD25+ Treg in human autoimmune diseases have been presented in the literature. Decreased numbers of peripheral blood Treg have been reported by most studies on SLE patients with active disease, but non-impaired or even increased CD4+CD25+ Treg numbers have also been described. In addition, both deficient and normal suppressive capacity of isolated Treg have been observed in SLE. Analysis of CD4+FoxP3+ Treg in skin lesions of patients with a primarily cutaneous manifestation of the disease showed a significant reduction in cell numbers as compared to other inflammatory skin diseases, suggesting the importance of analyzing Treg numbers in the affected tissue. In this review, we discuss the role of CD4+CD25+ Treg in autoimmunity and recent published data on SLE. Furthermore, we highlight the need for additional studies that address specific gaps of knowledge regarding the pathophysiological mechanisms as well as the identification of future therapeutic strategies for autoimmune diseases. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00403-008-0891-9Authors Annegret Kuhn, German Cancer Research Center Division of Immunogenetics, Tumor Immunology Program Heidelberg GermanyStefan Beissert, Westfälische Wilhelms-University Muenster Department of Dermatology Von-Esmarch-Strasse 58 48149 Muenster GermanyPeter H. Krammer, German Cancer Research Center Division of Immunogenetics, Tumor Immunology Program Heidelberg Germany Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest articles
Assessment of a new questionnaire for self-reported sun sensitivity in an occupational skin cancer screening program
Jurgen Tacke, Jens Dietrich, Beatrix Steinebrunner and Antonius Reifferscheid Fri, 24 Oct 2008 00:00:00 -0000
Background: Sun sensitivity of the skin is a risk factor for the development of cutaneous melanoma and other skin cancers. Epidemiological studies on causal factors for the development of melanoma must control for sun sensitivity as a confounder. A standardized instrument for measuring sun sensitivity has not been established yet. It is assumed that many studies show a high potential of residual confounding for sun sensitivity. In the present study, a new questionnaire for the assessment of self-reported sun sensitivity is administered and examined. Methods: Prior to an occupational skin cancer screening program, the 745 participating employees were asked to fill in a questionnaire for self-assessment of sun sensitivity. The questionnaire was developed by experts of the working group "Round Table Sunbeds" (RTS) to limit the health hazards of sunbed use in Germany. A sun sensitivity score (RTS-score) was calculated using 10 indicators. The internal consistency of the questionnaire and the agreement with other methods (convergent validity) were examined. Results: The RTS-score was calculated for 655 study participants who were 18 to 65 years of age. The correlation of the items among each other was between 0.12 and 0.62. The items and the RTS-score correlated between 0.46 and 0.77. The internal consistency showed a reliability coefficient of 0.82 (Cronbach`s alpha). The comparison with the Fitzpatrick classification, the prevailing standard, was possible in 617 cases with a rank correlation of rs=0.65. The categorization of the RTS-score in four risk groups showed correct classification to the four skin types of Fitzpatrick in 75 % of cases. Other methods for the assessment of sun sensitivity displayed varying agreements with the RTS-score. Conclusion: The RTS questionnaire showed a sufficient internal consistency. There is a good convergent validity between the RTS-score and the Fritzpatrick classification avoiding shortcomings of the prevailing standard. The questionnaire represents a simple, reliable and valid instrument for the assessment of sun sensitivity. It can be used in epidemiological studies as well as in skin cancer prevention programs. Further development and standardization of sun sensitivity assessments is necessary to strengthen the evidence of epidemiological studies on causal factors of melanoma and other skin cancers.
Sites:
Science University (OHSU) Department of Dermatology: OHSU Dermatology Department (Oregon Health & Science University): patient information, faculty, residency program, research, department newsBaylor College of Medicine Department of Dermatology: Home page for Baylor College of Medicine, Department of Dermatology
Brigham and Womens Hospital Dermatology Department -BWH: A Boston, Massachusetts hospital, Brigham and Womens Hospital is a leader in womens health issues, patient care and medical research. BWH is consistently named at the top of the US News and World Reports hospital rankings.
Columbia University Presbyterian Hospital Department of Dermatology: Basic science research group, skin diseases and hair research and treatment centers, New York, New York.
Competence Center for Hair and Hair Diseases: Das Kompetenzzentrum für Haare und Haarerkrankungen ist an der Klinik für Dermatologie am Universitätsklinikum Charité der Humboldt-Universität zu Berlin. Wir beschäftigen uns mit schwierigen Haarerkrankungen und Problemfällen und erforschen die wissenschaftlichen Hintergründe von ausgewÃ...
Duke University Division of Dermatology: Division of Dermatology
Emory Department of Dermatology: Faculty and staff, training and education, clinical services and research center, Atlanta, Georgia.
Harvard Medical School Department of Dermatology: The Harvard Medical School Department of Dermatology is an integral part of the Harvard-affiliated hospitals. The department's mission is to provide leadership in the field of dermatology in four key areas. The department emphasizes dermatological care, adaptation to changes in the delivery of h...
Harvard Skin Disease Research Center- HSDRC: Investigators, immunology and pilot studies, useful links as well as a description of specialized research cores.
Indiana University Department of Dermatology: Overview, faculty, residency and fellowship programs, patient referrals, staff and dermatological resources, Indianapolis, Indiana.
Johns Hopkins Department of Dermatology: Information for physicians on patient care, education, research and for patients on specialty clinics, research and department news, Baltimore, Maryland.
Mayo Clinic Department of Dermatology: Department of Dermatology, Mayo Clinic in Rochester, Minn.
Penn State Dermatology: Penn State Dermatology provides the highest quality medical and surgical care to patients with skin disease and skin disorders.
Skin Care Centre: British Columbia's Centre for dermatologic science, a partnership of the Vancouver hospital sciences centre and the university of British Columbia division of dermatology, Vancouver, Canada.
Stanford University School of Medicine Department of Dermatology: Department information, patient services, education and research,Stanford, California.
Texas Tech University Department of Dermatology: Clinic information, publications and residency program, Lubbock, Texas.
The Ronald O. Perelman Department of Dermatology at New York University: Education, research, clinical studies, faculty, seminars and conferences as well as news, New York City, New York.
Tulane University Department of Dermatology: Academic overview, faculty, clinical services, residency program, research and case of the week, New Orleans, Louisiana.
University of Arkansas for Medical Sciences: Department of Dermatology
University of Iowa Department of Dermatology: The Dept of Dermatology, Univ of Iowa College of Medicine provides the highest quality medical & surgical care to patients with skin disease. Our site provides information for patients and medical professionals about skin disorders.
University of Virginia Health System Department of Dermatology Welcome: This is the homepage for the Department of Dermatology
University of Washington Dermatology Division: University of Washington School of Medicine, Department of Medicine, Division of Dermatology, Seattle, Washington, The University of Washington Division of Dermatology identifies, trains, and sustains excellent scholars and future leaders in dermatology.
Utrecht University Medical Center Department of Dermatology: Overview of laboratory, research, and clinic, the Netherlands.
Yale University Department of Dermatology: The Department of Dermatology at Yale, one of the oldest in the country, is deeply rooted in research and is now the largest provider of specialized dermatologic care in the region. We have widely recognized strength in many clinical areas.
This directory is based on the Open Directory and may have been modified
