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Hypertension current issue
Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
O'Brien, E.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Parati, G., Bilo, G.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Verdecchia, P., Angeli, F., Mazzotta, G., Gentile, G., Reboldi, G.
Arteriosclerosis, Thrombosis, and Vascular Biology current issue
Tyrosine Sulfation of Leukocyte Adhesion Molecules and Chemokine Receptors Promotes Atherosclerosis [Editorials]
Koltsova, E., Ley, K.
Dimorphisms in the Membrane-Spanning Domain of EPCR Impact Systemic Coagulation [Editorials]
Esmon, C. T.
The Discovery of Cellular Immunity in the Atherosclerotic Plaque [History of Discovery]
Hansson, G. K., Jonasson, L. It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.
Circulation Research current issue
Controlling Myocyte cGMP: Phosphodiesterase 1 Joins the Fray [Editorials]
Takimoto, E.
Origin of Cardiac Fibroblasts and the Role of Periostin [Reviews]
Snider, P., Standley, K. N., Wang, J., Azhar, M., Doetschman, T., Conway, S. J. Abstract: Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chambers during heart development. Although there are currently no cardiac fibroblast-restricted molecular markers, it is generally envisaged that the majority of the cardiac fibroblasts are derived from the proepicardium via epithelial-to-mesenchymal transformation. However, still relatively little is known about when and where the cardiac fibroblasts cells are generated, the lineage of each cell, and how cardiac fibroblasts move to reside in their final position throughout all four cardiac chambers. In this review, we summarize the present understanding regarding the function of Periostin, a useful marker of the noncardiomyocyte lineages, and its role during cardiac morphogenesis. Characterization of the cardiac fibroblast lineage and identification of the signals that maintain, expand and regulate their differentiation will be required to improve our understanding of cardiac function in both normal and pathophysiological states.
Smooth Muscle Cell {alpha}2{delta}-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels [Cellular Biology]
Bannister, J. P., Adebiyi, A., Zhao, G., Narayanan, D., Thomas, C. M., Feng, J. Y., Jaggar, J. H. Rationale: Voltage-dependent L-type (CaV1.2) Ca2+ channels are a heteromeric complex formed from pore-forming 1 and auxiliary 2 and β subunits. CaV1.2 channels are the principal Ca2+ influx pathway in arterial myocytes and regulate multiple physiological functions, including contraction. The macromolecular composition of arterial myocyte CaV1.2 channels remains poorly understood, with no studies having examined the molecular identity or physiological functions of 2 subunits. Objective: We investigated the functional significance of 2 subunits in myocytes of resistance-size (100 to 200 µm diameter) cerebral arteries. Methods and Results: 2-1 was the only 2 isoform expressed in cerebral artery myocytes. Pregabalin, an 2-1/-2 ligand, and an 2-1 antibody, inhibited CaV1.2 currents in isolated myocytes. Acute pregabalin application reversibly dilated pressurized arteries. Using a novel application of surface biotinylation, data indicated that >95% of CaV1.2 1 and 2-1 subunits were present in the arterial myocyte plasma membrane. 2-1 knockdown using short hairpin RNA reduced plasma membrane-localized CaV1.2 1 subunits, caused a corresponding elevation in cytosolic CaV1.2 1 subunits, decreased intracellular Ca2+ concentration, inhibited pressure-induced vasoconstriction ("myogenic tone"), and attenuated pregabalin-induced vasodilation. Prolonged (24-hour) pregabalin exposure did not alter total 2-1 or CaV1.2 1 proteins but decreased plasma membrane expression of each subunit, which reduced myogenic tone. Conclusions: 2-1 is essential for plasma membrane expression of arterial myocyte CaV1.2 1 subunits. 2-1 targeting can block CaV1.2 channels directly and inhibit surface expression of CaV1.2 1 subunits, leading to vasodilation. These data identify 2-1 as a novel molecular target in arterial myocytes, the manipulation of which regulates contractility.
Hypertension current issue
Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
O'Brien, E.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Parati, G., Bilo, G.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Verdecchia, P., Angeli, F., Mazzotta, G., Gentile, G., Reboldi, G.
Subscribe to Journals RSS feed 
Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
O'Brien, E.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Parati, G., Bilo, G.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Verdecchia, P., Angeli, F., Mazzotta, G., Gentile, G., Reboldi, G.
Arteriosclerosis, Thrombosis, and Vascular Biology current issue
Tyrosine Sulfation of Leukocyte Adhesion Molecules and Chemokine Receptors Promotes Atherosclerosis [Editorials]
Koltsova, E., Ley, K.
Dimorphisms in the Membrane-Spanning Domain of EPCR Impact Systemic Coagulation [Editorials]
Esmon, C. T.
The Discovery of Cellular Immunity in the Atherosclerotic Plaque [History of Discovery]
Hansson, G. K., Jonasson, L. It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.
Circulation Research current issue
Controlling Myocyte cGMP: Phosphodiesterase 1 Joins the Fray [Editorials]
Takimoto, E.
Origin of Cardiac Fibroblasts and the Role of Periostin [Reviews]
Snider, P., Standley, K. N., Wang, J., Azhar, M., Doetschman, T., Conway, S. J. Abstract: Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chambers during heart development. Although there are currently no cardiac fibroblast-restricted molecular markers, it is generally envisaged that the majority of the cardiac fibroblasts are derived from the proepicardium via epithelial-to-mesenchymal transformation. However, still relatively little is known about when and where the cardiac fibroblasts cells are generated, the lineage of each cell, and how cardiac fibroblasts move to reside in their final position throughout all four cardiac chambers. In this review, we summarize the present understanding regarding the function of Periostin, a useful marker of the noncardiomyocyte lineages, and its role during cardiac morphogenesis. Characterization of the cardiac fibroblast lineage and identification of the signals that maintain, expand and regulate their differentiation will be required to improve our understanding of cardiac function in both normal and pathophysiological states.
Smooth Muscle Cell {alpha}2{delta}-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels [Cellular Biology]
Bannister, J. P., Adebiyi, A., Zhao, G., Narayanan, D., Thomas, C. M., Feng, J. Y., Jaggar, J. H. Rationale: Voltage-dependent L-type (CaV1.2) Ca2+ channels are a heteromeric complex formed from pore-forming 1 and auxiliary 2 and β subunits. CaV1.2 channels are the principal Ca2+ influx pathway in arterial myocytes and regulate multiple physiological functions, including contraction. The macromolecular composition of arterial myocyte CaV1.2 channels remains poorly understood, with no studies having examined the molecular identity or physiological functions of 2 subunits. Objective: We investigated the functional significance of 2 subunits in myocytes of resistance-size (100 to 200 µm diameter) cerebral arteries. Methods and Results: 2-1 was the only 2 isoform expressed in cerebral artery myocytes. Pregabalin, an 2-1/-2 ligand, and an 2-1 antibody, inhibited CaV1.2 currents in isolated myocytes. Acute pregabalin application reversibly dilated pressurized arteries. Using a novel application of surface biotinylation, data indicated that >95% of CaV1.2 1 and 2-1 subunits were present in the arterial myocyte plasma membrane. 2-1 knockdown using short hairpin RNA reduced plasma membrane-localized CaV1.2 1 subunits, caused a corresponding elevation in cytosolic CaV1.2 1 subunits, decreased intracellular Ca2+ concentration, inhibited pressure-induced vasoconstriction ("myogenic tone"), and attenuated pregabalin-induced vasodilation. Prolonged (24-hour) pregabalin exposure did not alter total 2-1 or CaV1.2 1 proteins but decreased plasma membrane expression of each subunit, which reduced myogenic tone. Conclusions: 2-1 is essential for plasma membrane expression of arterial myocyte CaV1.2 1 subunits. 2-1 targeting can block CaV1.2 channels directly and inhibit surface expression of CaV1.2 1 subunits, leading to vasodilation. These data identify 2-1 as a novel molecular target in arterial myocytes, the manipulation of which regulates contractility.
Hypertension current issue
Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
O'Brien, E.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Parati, G., Bilo, G.
Response to Home Blood Pressure Measurements Will or Will Not Replace 24-Hour Ambulatory Blood Pressure Measurement [Letters to the Editor]
Verdecchia, P., Angeli, F., Mazzotta, G., Gentile, G., Reboldi, G.
Sites:
of Cardiology: Web-based publication covering topics submitted by the medical community. Features case reports, editorials, images and peer reviewed articles.American Heart Journal: A monthly publication for cardiologists and general practice physicians. Includes clinical trial data, key findings from cardiovascular meetings and treatment cost-effectiveness.
Blood Pressure Monitoring: Provides access to full-text and online-only content, features and services, author submission materials and title-specific information.
Cardiology Clinics: Publication that focuses on a single topic per issue. Features reviews providing information on current diagnosis and treatment methods.
Cardiology in Review: Features reviews of the pathogenesis, diagnosis, clinical course and treatment of cardiovascular disorders. Includes author guidelines, editorial board and subscription information.
Cardiology in the Young: Bi-monthly publication focusing on issues of heart disease acquired in childhood. Includes original articles, editorials and continuing medical education papers.
Circulation: Weekly publication from the American Heart Association. Includes peer-reviewed reports on clinical and laboratory research and archives available from 1965 to present.
Circulation Research: Presents results of bench studies with subcategories including molecular medicine, cell biology and integrative physiology.
Coronary Artery Disease: Features articles on coronary artery disease with a clinical emphasis. Includes observational studies, clinical trials, and advances in laboratory research.
Current Atherosclerosis Reports: Literature review journal covering the latest research, clinical studies, and pharmacologic advances. Requires subscription.
Current Controlled Trials in Cardiovascular Medicine: Publishes clinical trial protocols, papers reporting interim and final results and original research.
Current Opinion in Cardiology: Bi-monthly resource featuring reviews and editorials on developments in valvular heart disease treatment, transplantation and pediatrics.
E-chocardiography Journal: An online publication from the University of Medicine and Dentistry, New Jersey. Includes articles, sample images, auscultation essays and an e-mail discussion group.
European Heart Journal: International peer-reviewed journal with research articles, technical evaluations, and reviews.
European Heart Journal Supplements: Supplements to the European Heart Journal, an international, peer-reviewed journal dealing with cardiovascular medicine.
European Journal of Echocardiography: Official publication of the European Association of Echocardiography. Features original peer-reviewed articles, technical evaluations, case reports and guest editorials.
European Society of Cardiology Journals: From this site, discover how to access content, subscribe and submit articles to each of the 7 official ESC journals.
Expert Review of Cardiovascular Therapy: Discusses the clinical applications of new medicines, therapeutic agents and diagnostics in this field.
Heart: Heart, a peer review journal for health professionals and researchers in all areas of cardiology
Heart Disease: Focuses on strategies for the prevention and management of disease. Includes articles on new therapeutics, surgical approaches and alternative medicine.
Heart Journal: Monthly web-based publication from Cairo University. Includes clinical cases, ECG discussion and review articles. [English and Arabic]
Heart Surgery Forum: The Heart Surgery Forum is an online peer-reviewed journal in Cardiothoracic Surgery offering scientific articles, multimedia presentations, discussion boards, news, announcements and more.
Hypertension: Monthly publication by the American Heart Association focusing on blood pressure regulation and pathophysiological mechanisms underlying hypertensive diseases. Includes peer-reviewed reports, articles and editorials.
Images in Paediatric Cardiology: On-line, peer-reviewed, pediatric, cardiology, journal. Home page.
Indian Pacing and Electrophysiology Journal: Indian Pacing and Electrophysiology Journal
Journal of Cardiovascular Risk: Addresses the causes and prevention of cardiovascular disease, as well as rehabilitation and exercise physiology. Includes original papers, editorials and clinical practices.
Journal of Clinical and Basic Cardiology: Austrian publication featuring original papers describing current research, observational studies and clinical trials. [Articles in English]
Journal of Endovascular Therapy: Welcome to the Journal of Endovascular Therapy (formerly Journal of Endovascular Surgery), a peer-reviewed online medical journal dedicated to peripheral vascular disease interventions. The Journal, an official publication of the International Society of Endovascular Specialists, features bim...
Journal of Interesting Electrocardiogram: resource center for electrocardiograms and electrocardiography
Journal of the American College of Cardiology: Includes original peer-reviewed clinical and experimental reports, new diagnostic techniques, clinical reviews and editorial commentary.
Journal of the Renin-Angiotensin-Aldosterone System (JRAAS): The Journal of the Renin-Angiotensin-Aldosterone System (JRAAS) provides the only scientific journal devoted exclusively to these developments. It includes: Original research on these peptide systems, clinical research reports on the blockade of the RAAS, results of clinical trials of drugs inhib...
Journal Watch Cardiology: Summaries and commentary of cardiology medical journal articles covering topics such as coronary artery disease and hypertension.
Nature Clinical Practice Cardiovascular Medicine: Nature Clinical Practice Cardiovascular Medicine will deliver timely interpretations of key research developments, translating the latest findings into clinical practice. Our Editor-in-Chief and international Advisory Board will ensure comprehensive coverage of topical issues throughout the year,...
Pediatric Cardiology Today: Monthly newsletter written by physicians, available in print or as PDF files online. Provides information on patient therapy, training opportunities and products and services.
Progress in Pediatric Cardiology: Presenting information and experienced opinion to aid in understanding and managing cardiovascular diseases in children.
Stroke: Journal of the American Stroke Association. Free searchable table of contents and abstracts from current and past issues as well as e-mail alerts. Full-text access by subscription only.
Texas Heart Institute Journal: The Texas Heart Institute Journal is published quarterly by the Texas Heart Institute, Houston, Texas.
The Journal of Hypertension: Official monthly journal of the European Society of Hypertension and International Society of Hypertension. Full articles available online.
This directory is based on the Open Directory and may have been modified
